Mechanisms of thrombophilia
نویسنده
چکیده
The term thrombophilia describes the predisposition to venous thromboembolism and, under certain circumstances, also an increased risk of arterial thrombosis. In a broad sense, thrombophilia includes any inherited or acquired disorder associated with an increased tendency to thrombosis. It was soon realised that thrombotic events have a complex multifactorial cause, usually a combination of genetic factors combined with acquired haematological disorders. Besides, behavioural factors, as diet or exercise, influence the incidence of thrombosis, making it difficult to asses the risk of thrombosis in a given individual. In any case, inherited thrombophilia is one of the main determinants of venous thromboembolism (VTE), and the presence of inherited thrombophilic defects exposes carriers to increased risks for VTE compared with non-carriers. The presence of hereditary thrombophilia should be considered in patients with a documented unexplained thrombotic episode or a positive family history. There is no clear relationship between clinical manifestations and the type of underlying thrombophilic defect. Thus, diagnosis of inherited thrombophilia has to be established on a laboratory basis.
منابع مشابه
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تاریخ انتشار 2014